Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50047499
Substrate
n/a
Meas. Tech.
ChEMBL_28334 (CHEMBL645898)
IC50
43±n/a nM
Citation
 Kimura, T; Watanabe, N; Matsui, M; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Kabayashi, H; Akasaka, K Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2. J Med Chem 36:1641-53 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50047499
Synonyms:
1-{2-Dimethylamino-6-[3-(5-methyl-4-phenyl-imidazol-1-yl)-propoxy]-phenyl}-3-pentyl-urea | CHEMBL296094
Type:
Small organic molecule
Emp. Form.:
C27H37N5O2
Mol. Mass.:
463.615
SMILES:
CCCCCNC(=O)Nc1c(OCCCn2cnc(c2C)-c2ccccc2)cccc1N(C)C
Structure:
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