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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50022279
Substrate
n/a
Meas. Tech.
ChEMBL_28334 (CHEMBL645898)
IC50
180±n/a nM
Citation
 Kimura, T; Watanabe, N; Matsui, M; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Kabayashi, H; Akasaka, K Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2. J Med Chem 36:1641-53 (1993) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50022279
Synonyms:
3-(2,4-Difluoro-phenyl)-1-[4-(2,2-dimethyl-propyl)-benzyl]-1-heptyl-urea | CHEMBL277986 | CL-277082
Type:
Small organic molecule
Emp. Form.:
C26H36F2N2O
Mol. Mass.:
430.5736
SMILES:
CCCCCCCN(Cc1ccc(CC(C)(C)C)cc1)C(=O)Nc1ccc(F)cc1F
Structure:
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