Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50047565
Substrate
n/a
Meas. Tech.
ChEMBL_28334 (CHEMBL645898)
IC50
>1000±n/a nM
Citation
Kimura, T; Watanabe, N; Matsui, M; Hayashi, K; Tanaka, H; Ohtsuka, I; Saeki, T; Kogushi, M; Kabayashi, H; Akasaka, K Structure-activity relationship of a series of phenylureas linked to 4-phenylimidazole. Novel potent inhibitors of acyl-CoA:cholesterol O-acyltransferase with antiatherosclerotic activity. 2. J Med Chem 36:1641-53 (1993) [PubMed] Article
More Info.:
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
Inhibitor
Name:
BDBM50047565
Synonyms:
CHEMBL42498 | N-[3-(1-{3-[3-Methyl-2-(3-pentyl-ureido)-phenoxy]-propyl}-1H-imidazol-4-yl)-phenyl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C26H35N5O4S
Mol. Mass.:
513.652
SMILES:
CCCCCNC(=O)Nc1c(C)cccc1OCCCn1cnc(c1)-c1cccc(NS(C)(=O)=O)c1