Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50048612
Substrate
n/a
Meas. Tech.
ChEMBL_138692 (CHEMBL747659)
IC50
5100±n/a nM
Citation
 Davis, L; Olsen, GE; Klein, JT; Kapples, KJ; Huger, FP; Smith, CP; Petko, WW; Cornfeldt, M; Effland, RC Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease. J Med Chem 39:582-7 (1996) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50048612
Synonyms:
CHEMBL350442 | Methyl-pyridin-4-yl-(2-vinyl-pyrrol-1-yl)-amine
Type:
Small organic molecule
Emp. Form.:
C12H13N3
Mol. Mass.:
199.2517
SMILES:
CN(c1ccncc1)n1cccc1C=C
Structure:
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