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Target
D(2) dopamine receptor
Ligand
BDBM50048810
Substrate
n/a
Meas. Tech.
ChEMBL_61415 (CHEMBL675883)
IC50
1100±n/a nM
Citation
 Norman, MH; Minick, DJ; Rigdon, GC Effect of linking bridge modifications on the antipsychotic profile of some phthalimide and isoindolinone derivatives. J Med Chem 39:149-57 (1996) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50048810
Synonyms:
2-[4-(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-but-2-ynyl]-2,3-dihydro-isoindol-1-one | CHEMBL559330
Type:
Small organic molecule
Emp. Form.:
C23H22N4OS
Mol. Mass.:
402.512
SMILES:
O=C1N(CC#CCN2CCN(CC2)c2nsc3ccccc23)Cc2ccccc12
Structure:
Search PDB for entries with ligand similarity: