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Target
Cholecystokinin receptor type A
Ligand
BDBM50049790
Substrate
n/a
Meas. Tech.
ChEMBL_50056 (CHEMBL662425)
IC50
3000±n/a nM
Citation
 Castro, JL; Ball, RG; Broughton, HB; Russell, MG; Rathbone, D; Watt, AP; Baker, R; Chapman, KL; Fletcher, AE; Patel, S; Smith, AJ; Marshall, GR; Ryecroft, W; Matassa, VG Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas. J Med Chem 39:842-9 (1996) [PubMed]  Article 
Target
Name:
Cholecystokinin receptor type A
Synonyms:
CCKAR_RAT | Cckar | Cholecystokinin peripheral | Cholecystokinin receptor | Cholecystokinin receptor type A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49676.37
Organism:
RAT
Description:
Cholecystokinin central 0 RAT::P30551
Residue:
444
Sequence:
MSHSPARQHLVESSRMDVVDSLLMNGSNITPPCELGLENETLFCLDQPQPSKEWQSALQILLYSIIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYSNLVPFTKNNNQTANMCRFLLPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYEDSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTVSAEKHLSGTPISFILLLSYTSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP
  
Inhibitor
Name:
BDBM50049790
Synonyms:
1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-3-[3-(1H-tetrazol-5-ylamino)-phenyl]-urea | CHEMBL169362
Type:
Small organic molecule
Emp. Form.:
C24H21N9O2
Mol. Mass.:
467.4826
SMILES:
CN1c2ccccc2C(=N[C@@H](NC(=O)Nc2cccc(Nc3nnn[nH]3)c2)C1=O)c1ccccc1 |c:9|
Structure:
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