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Target
Endothelin receptor type B
Ligand
BDBM50050057
Substrate
n/a
Meas. Tech.
ChEMBL_63697 (CHEMBL670653)
IC50
>90000±n/a nM
Citation
 von Geldern, TW; Hoffman, DJ; Kester, JA; Nellans, HN; Dayton, BD; Calzadilla, SV; Marsh, KC; Hernandez, L; Chiou, W; Dixon, DB; Wu-Wong, JR; Opgenorth, TJ Azole endothelin antagonists. 3. Using delta log P as a tool to improve absorption. J Med Chem 39:982-91 (1996) [PubMed]  Article 
Target
Name:
Endothelin receptor type B
Synonyms:
EDNRB | EDNRB_HUMAN | ENDOTHELIN B | ET-B | ETRB | Endothelin receptor ET-B | Endothelin receptor non-selective type | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49664.00
Organism:
Homo sapiens (Human)
Description:
ENDOTHELIN B EDNRB HUMAN::P24530
Residue:
442
Sequence:
MQPPPSLCGRALVALVLACGLSRIWGEERGFPPDRATPLLQTAEIMTPPTKTLWPKGSNASLARSLAPAEVPKGDRTAGSPPRTISPPPCQGPIEIKETFKYINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLHIVIDIPINVYKLLAEDWPFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSVVLAVPEAIGFDIITMDYKGSYLRICLLHPVQKTAFMQFYKTAKDWWLFSFYFCLPLAITAFFYTLMTCEMLRKKSGMQIALNDHLKQRREVAKTVFCLVLVFALCWLPLHLSRILKLTLYNQNDPNRCELLSFLLVLDYIGINMASLNSCINPIALYLVSKRFKNCFKSCLCCWCQSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKYSSS
  
Inhibitor
Name:
BDBM50050057
Synonyms:
2-[(R)-1-[(S)-2-(2-Cyclohexyl-acetylamino)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-1H-imidazole-4-carboxylic acid | CHEMBL174871
Type:
Small organic molecule
Emp. Form.:
C30H41N5O4
Mol. Mass.:
535.6776
SMILES:
CC(C)C[C@H](NC(=O)CC1CCCCC1)C(=O)N[C@H](Cc1cn(C)c2ccccc12)c1nc(C(O)=O)c(C)[nH]1
Structure:
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