Target
Dihydrofolate reductase
Ligand
BDBM50050400
Substrate
n/a
Meas. Tech.
ChEMBL_52980 (CHEMBL664188)
IC50
210±n/a nM
Citation
 Piper, JRJohnson, CAKrauth, CACarter, RLHosmer, CAQueener, SFBorotz, SEPfefferkorn, ER Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 39:1271-80 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50050400
Synonyms:
6-(Naphthalen-1-ylaminomethyl)-quinazoline-2,4-diamine | CHEMBL23211
Type:
Small organic molecule
Emp. Form.:
C19H17N5
Mol. Mass.:
315.3718
SMILES:
Nc1nc(N)c2cc(CNc3cccc4ccccc34)ccc2n1
Structure:
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