Target
Dihydrofolate reductase
Ligand
BDBM50050418
Substrate
n/a
Meas. Tech.
ChEMBL_52980 (CHEMBL664188)
IC50
97000±n/a nM
Citation
 Piper, JRJohnson, CAKrauth, CACarter, RLHosmer, CAQueener, SFBorotz, SEPfefferkorn, ER Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 39:1271-80 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_PNECA | Dihydrofolate Reductase (DHFR) | Dihydrofolate reductase | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
23891.29
Organism:
Pneumocystis carinii
Description:
n/a
Residue:
206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRKTWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRIFVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESWVGTKVPHGKINEDGFDYEFEMWTRDL
  
Inhibitor
Name:
BDBM50050418
Synonyms:
6-(2-Naphthalen-1-yl-ethyl)-pteridine-2,4-diamine | CHEMBL276954
Type:
Small organic molecule
Emp. Form.:
C18H16N6
Mol. Mass.:
316.3598
SMILES:
Nc1nc(N)c2nc(CCc3cccc4ccccc34)cnc2n1
Structure:
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