Target
Dihydrofolate reductase
Ligand
BDBM50050384
Substrate
n/a
Meas. Tech.
ChEMBL_55115 (CHEMBL665442)
IC50
470±n/a nM
Citation
 Piper, JRJohnson, CAKrauth, CACarter, RLHosmer, CAQueener, SFBorotz, SEPfefferkorn, ER Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 39:1271-80 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50050384
Synonyms:
6-{[(2,5-Dimethoxy-phenyl)-methyl-amino]-methyl}-pteridine-2,4-diamine | CHEMBL22543
Type:
Small organic molecule
Emp. Form.:
C16H19N7O2
Mol. Mass.:
341.3678
SMILES:
COc1ccc(OC)c(c1)N(C)Cc1cnc2nc(N)nc(N)c2n1
Structure:
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