Target
Dihydrofolate reductase
Ligand
BDBM50034929
Substrate
n/a
Meas. Tech.
ChEMBL_55115 (CHEMBL665442)
IC50
370±n/a nM
Citation
 Piper, JRJohnson, CAKrauth, CACarter, RLHosmer, CAQueener, SFBorotz, SEPfefferkorn, ER Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations. J Med Chem 39:1271-80 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50034929
Synonyms:
6-[(2,5-Diethoxy-phenylamino)-methyl]-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | 6-{[(2,5-DIETHOXYPHENYL)AMINO]METHYL}-5-METHYLPYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE | CHEMBL279679
Type:
Small organic molecule
Emp. Form.:
C19H24N6O2
Mol. Mass.:
368.4329
SMILES:
CCOc1ccc(OCC)c(NCc2cnc3nc(N)nc(N)c3c2C)c1
Structure:
Search PDB for entries with ligand similarity: