Reaction Details Report a problem with these data
Target
Adenylate cyclase type 5
Ligand
BDBM50009854
Substrate
n/a
Meas. Tech.
ChEMBL_31438 (CHEMBL645311)
EC50
275±n/a nM
Citation
 Yamada, K; Rice, KC; Flippen-Anderson, JL; Eissenstat, MA; Ward, SJ; Johnson, MR; Howlett, AC (Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor. J Med Chem 39:1967-74 (1996) [PubMed]  Article 
Target
Name:
Adenylate cyclase type 5
Synonyms:
ADCY5_RAT | ATP pyrophosphate-lyase 5 | Adcy5 | Adenylate cyclase type 5 | Adenylate cyclase type IX | Adenylate cyclase type V | Adenylyl cyclase 5
Type:
PROTEIN
Mol. Mass.:
139188.88
Organism:
Rattus norvegicus
Description:
ChEMBL_31725
Residue:
1262
Sequence:
MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGAVTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGGRGSRRQRRGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVGLEERRGKGRAAEELEPGTGTVEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGSPQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
  
Inhibitor
Name:
BDBM50009854
Synonyms:
CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol-3-yl]-naphthalen-1-yl-methanone
Type:
Small organic molecule
Emp. Form.:
C25H24N2O2
Mol. Mass.:
384.4703
SMILES:
O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12
Structure:
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