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Target
Sterol O-acyltransferase 1
Ligand
BDBM50050741
Substrate
n/a
Meas. Tech.
ChEMBL_28794 (CHEMBL641704)
IC50
700±n/a nM
Citation
 Vaccaro, W; Amore, C; Berger, J; Burrier, R; Clader, J; Davis, H; Domalski, M; Fevig, T; Salisbury, B; Sher, R Inhibitors of acyl CoA:cholesterol acyltransferase. J Med Chem 39:1704-19 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50050741
Synonyms:
CHEMBL296219 | N-[(1S,2R)-2-(4-Amino-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-2,2-diphenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C30H28N2O
Mol. Mass.:
432.5561
SMILES:
Nc1ccc(cc1)[C@H]1CCc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1
Structure:
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