Target
Sterol O-acyltransferase 1
Ligand
BDBM50051883
Substrate
n/a
Meas. Tech.
ChEMBL_28661 (CHEMBL643995)
IC50
60±n/a nM
Citation
 Astles, PCAshton, MJBridge, AWHarris, NVHart, TWParrott, DPPorter, BRiddell, DSmith, CWilliams, RJ Acyl-CoA:Cholesterol O-acyltransferase (ACAT) inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1H-imidazoles as potent inhibitors of ACAT. J Med Chem 39:1423-32 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACACT | ACACT1 | ACAT | ACAT1 | Acetyl-CoA acetyltransferase, mitochondrial | Acyl coenzyme A:cholesterol acyltransferase 1 | Acyl-CoA: cholesterol acyltransferase (ACAT) | Acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1) | Cholesterol acyltransferase 1 | SOAT | SOAT1 | SOAT1_HUMAN | STAT
Type:
Multi-pass membrane protein may form homo- or heterodimers.
Mol. Mass.:
64751.94
Organism:
Homo sapiens (Human)
Description:
P35610
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50051883
Synonyms:
1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[1,3]dioxan-5-yl]-pentyl}-3,5-dimethyl-1H-pyrazole | CHEMBL285429
Type:
Small organic molecule
Emp. Form.:
C30H36N4O2
Mol. Mass.:
484.6324
SMILES:
Cc1cc(C)n(CCCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 |(10.96,-4.93,;10.8,-6.47,;9.47,-7.23,;9.8,-8.75,;8.77,-9.89,;11.34,-8.91,;12.12,-10.26,;11.03,-11.35,;11.8,-12.69,;11.05,-14.02,;11.83,-15.36,;11.84,-16.9,;13.17,-17.67,;11.08,-18.24,;9.36,-17.63,;8.18,-18.05,;8.94,-16.7,;10.57,-17.32,;6.84,-17.28,;6.43,-15.79,;4.9,-15.72,;4.34,-17.16,;5.55,-18.12,;2.85,-17.56,;1.77,-16.47,;.29,-16.88,;-.11,-18.37,;.99,-19.45,;2.47,-19.05,;4.04,-14.43,;4.74,-13.06,;3.9,-11.77,;2.36,-11.85,;1.68,-13.23,;2.52,-14.51,;11.96,-7.49,)|
Structure:
Search PDB for entries with ligand similarity: