Target
Glutathione reductase, mitochondrial
Ligand
BDBM50051994
Substrate
n/a
Meas. Tech.
ChEMBL_72475 (CHEMBL685508)
IC50
4000±n/a nM
Citation
 Schönleben-Janas, AKirsch, PMittl, PRSchirmer, RHKrauth-Siegel, RL Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies. J Med Chem 39:1549-54 (1996) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50051994
Synonyms:
10-Anthracen-1-yl-3-methyl-10H-benzo[g]pteridine-2,4-dione | CHEMBL38899
Type:
Small organic molecule
Emp. Form.:
C25H16N4O2
Mol. Mass.:
404.4201
SMILES:
Cn1c(=O)nc2n(-c3cccc4cc5ccccc5cc34)c3ccccc3nc2c1=O |(19.16,-12.07,;17.82,-11.33,;17.81,-9.76,;19.13,-8.98,;16.47,-9.02,;15.12,-9.79,;13.8,-9.03,;13.77,-7.52,;15.09,-6.75,;15.09,-5.21,;13.74,-4.46,;12.45,-5.21,;11.1,-4.47,;9.76,-5.26,;8.45,-4.5,;7.12,-5.27,;7.13,-6.81,;8.47,-7.57,;9.79,-6.78,;11.11,-7.54,;12.45,-6.75,;12.46,-9.82,;11.13,-9.05,;9.8,-9.82,;9.8,-11.36,;11.13,-12.13,;12.46,-11.36,;13.81,-12.13,;15.14,-11.34,;16.49,-12.11,;16.5,-13.65,)|
Structure:
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