Target
Glutathione reductase, mitochondrial
Ligand
BDBM50052012
Substrate
n/a
Meas. Tech.
ChEMBL_72475 (CHEMBL685508)
IC50
18000±n/a nM
Citation
 Schönleben-Janas, AKirsch, PMittl, PRSchirmer, RHKrauth-Siegel, RL Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies. J Med Chem 39:1549-54 (1996) [PubMed]  Article 
Target
Name:
Glutathione reductase, mitochondrial
Synonyms:
GLUR | GRD1 | GSHR_HUMAN | GSR | Glutathione reductase | Glutathione reductase (GR)
Type:
Enzyme
Mol. Mass.:
56271.52
Organism:
Homo sapiens (Human)
Description:
P00390
Residue:
522
Sequence:
MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAGAVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHSEFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR
  
Inhibitor
Name:
BDBM50052012
Synonyms:
CHEMBL418250 | [10-(4-Chloro-phenyl)-2,4-dioxo-4,10-dihydro-2H-benzo[g]pteridin-3-yl]-acetic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C20H15ClN4O4
Mol. Mass.:
410.811
SMILES:
CCOC(=O)Cn1c(=O)nc2n(-c3ccc(Cl)cc3)c3ccccc3nc2c1=O
Structure:
Search PDB for entries with ligand similarity: