Target
Monoglyceride lipase
Ligand
BDBM50503344
Substrate
n/a
Meas. Tech.
ChEMBL_1810393 (CHEMBL4309853)
IC50
48±n/a nM
Citation
 Cisar, JSWeber, ODClapper, JRBlankman, JLHenry, CLSimon, GMAlexander, JPJones, TKEzekowitz, RABO'Neill, GPGrice, CA Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders. J Med Chem 61:9062-9084 (2018) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50503344
Synonyms:
CHEMBL4439400
Type:
Small organic molecule
Emp. Form.:
C22H24F9N3O3
Mol. Mass.:
549.4299
SMILES:
[H][C@]12CC[C@]([H])(COC1)N2c1cc(ccc1CN1CCN(CC1)C(=O)OC(C(F)(F)F)C(F)(F)F)C(F)(F)F |r|
Structure:
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