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TargetInosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
LigandBDBM50054007
Substrate/Competitorn/a
Meas. Tech.ChEMBL_89808
IC50 763±n/a nM
Citation Nelson, PHCarr, SFDevens, BHEugui, EMFranco, FGonzalez, CHawley, RCLoughhead, DGMilan, DJPapp, EPatterson, JWRouhafza, SSjogren, EBSmith, DBStephenson, RATalamas, FXWaltos, AMWeikert, RJWu, JC Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase by nuclear variants of mycophenolic acid. J Med Chem39:4181-96 (1996) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2)
Name:Inosine-5'-monophosphate dehydrogenase (IMPDH)
Synonyms:IMP dehydrogenase 2 | IMPD 2 | IMPDH-II | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5''''-monophosphate dehydrogenase 2
Type:Enzyme
Mol. Mass.:55806.87
Organism:Homo sapiens (Human)
Description:Recombinant IMPDH2 expressed in E. coli.
Residue:514
Sequence:
MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50054007
NameBDBM50054007
Synonyms:(E)-6-(2-Amino-3-bromo-4,5,6-trimethyl-phenyl)-4-methyl-hex-4-enoic acid | CHEMBL114426
TypeSmall organic molecule
Emp. Form.C16H22BrNO2
Mol. Mass.340.255
SMILESC\C(CCC(O)=O)=C/Cc1c(C)c(C)c(C)c(Br)c1N
Structure
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