Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50054143
Substrate
n/a
Meas. Tech.
ChEMBL_60193 (CHEMBL879565)
IC50
23300±n/a nM
Citation
Comoy, C; Marot, C; Podona, T; Baudin, ML; Morin-Allory, L; Guillaumet, G; Pfeiffer, B; Caignard, DH; Renard, P; Rettori, MC; Adam, G; Guardiola-Lemaitre, B 3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans] J Med Chem 39:4285-98 (1996) [PubMed] Article
More Info.:
Target
Name:
D(1A) dopamine receptor
Synonyms:
D(1A) dopamine receptor | D1AR | DOPAMINE D1 | DRD1 | DRD1_BOVIN | Dopamine receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49330.65
Organism:
BOVINE
Description:
DOPAMINE D1 DRD1 BOVINE::Q95136
Residue:
446
Sequence:
MRTLNTSTMEGTGLVAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTGPSEGNATSLGKTINNCDSSLSRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIRRISALERAAVHAKNCQTTTGNGNPMECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCGSGETKPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNVVYLIPHAVGSSEGLKKEEAVGIAKPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
Inhibitor
Name:
BDBM50054143
Synonyms:
(+) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | (+/-) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | (-) 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | 8-{4-[5-methoxyspiro[3,4-dihydro-2H-chromene-3,2'-(tetrahydro-1'H-pyrrole)]-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione | CHEMBL11265
Type:
Small organic molecule
Emp. Form.:
C26H36N2O4
Mol. Mass.:
440.575
SMILES:
COc1cccc2OCC3(CCCN3CCCCN3C(=O)CC4(CCCC4)CC3=O)Cc12