Reaction Details Report a problem with these data
Target
Transcriptional activator protein LasR
Ligand
BDBM50465703
Substrate
n/a
Meas. Tech.
ChEMBL_1816423 (CHEMBL4315997)
IC50
50000±n/a nM
Citation
 Hossain, MA; Sattenapally, N; Parikh, HI; Li, W; Rumbaugh, KP; German, NA Design, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence. Eur J Med Chem 185:0 (2020) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50465703
Synonyms:
CHEMBL1823945
Type:
Small organic molecule
Emp. Form.:
C20H14Cl2N2O2
Mol. Mass.:
385.243
SMILES:
Clc1cccc(c1)C(=O)Nc1ccccc1NC(=O)c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: