Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50505387
Substrate
n/a
Meas. Tech.
ChEMBL_1822663 (CHEMBL4322427)
Ki
1.8±n/a nM
Citation
 Falsini, M; Catarzi, D; Varano, F; Ceni, C; Dal Ben, D; Marucci, G; Buccioni, M; Volpini, R; Di Cesare Mannelli, L; Lucarini, E; Ghelardini, C; Bartolucci, G; Menicatti, M; Colotta, V Antioxidant-Conjugated 1,2,4-Triazolo[4,3- J Med Chem 62:8511-8531 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50505387
Synonyms:
CHEMBL4452162
Type:
Small organic molecule
Emp. Form.:
C20H16N6O2
Mol. Mass.:
372.38
SMILES:
Nc1nc(cn2c1nn(-c1ccccc1)c2=O)-c1ccc(NC(=O)C=C)cc1
Structure:
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