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Target
Reverse transcriptase/RNaseH
Ligand
BDBM50057814
Substrate
n/a
Meas. Tech.
ChEMBL_197125 (CHEMBL803726)
EC50
114000±n/a nM
Citation
 Adams, DR; Perez, C; Maillard, M; Florent, JC; Evers, M; Hénin, Y; Litvak, S; Litvak, L; Monneret, C; Grierson, DS Preparation and anti-HIV activity of N-3-substituted thymidine nucleoside analogs. J Med Chem 40:1550-8 (1997) [PubMed]  Article 
Target
Name:
Reverse transcriptase/RNaseH
Synonyms:
HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH
Type:
PROTEIN
Mol. Mass.:
65229.15
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_1473730
Residue:
566
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGAHTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQAIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKVLFLDGID
  
Inhibitor
Name:
BDBM50057814
Synonyms:
2-{2-[3-(4-Azido-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-ethyl}-isoindole-1,3-dione | CHEMBL290236
Type:
Small organic molecule
Emp. Form.:
C20H20N6O6
Mol. Mass.:
440.4094
SMILES:
Cc1cn(C2CC(N=[N+]=[N-])C(CO)O2)c(=O)n(CCN2C(=O)c3ccccc3C2=O)c1=O
Structure:
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