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Target
Neutrophil elastase
Ligand
BDBM50058482
Substrate
n/a
Meas. Tech.
ChEMBL_63796 (CHEMBL679049)
IC50
70±n/a nM
Citation
 Portevin, B; Lonchampt, M; Canet, E; De Nanteuil, G Dual inhibition of human leukocyte elastase and lipid peroxidation: in vitro and in vivo activities of azabicyclo[2.2.2]octane and perhydroindole derivatives. J Med Chem 40:1906-18 (1997) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50058482
Synonyms:
(S)-1-{(R)-2-[4-(4-Chloro-benzenesulfonylaminocarbonyl)-benzoylamino]-6-[2-(3,5-di-tert-butyl-4-hydroxy-phenyl)-acetylamino]-hexanoyl}-octahydro-indole-2-carboxylic acid (3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-amide | CHEMBL276166
Type:
Small organic molecule
Emp. Form.:
C51H65ClF3N5O9S
Mol. Mass.:
1016.603
SMILES:
CC(C)C(NC(=O)[C@@H]1CC2CCCCC2N1C(=O)[C@@H](CCCCNC(=O)Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)NC(=O)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(Cl)cc1)C(=O)C(F)(F)F
Structure:
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