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Target
D(4) dopamine receptor
Ligand
BDBM50059223
Substrate
n/a
Meas. Tech.
ChEMBL_60829 (CHEMBL675818)
Ki
110±n/a nM
Citation
 Rowley, M; Collins, I; Broughton, HB; Davey, WB; Baker, R; Emms, F; Marwood, R; Patel, S; Patel, S; Ragan, CI; Freedman, SB; Ball, R; Leeson, PD 4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor. J Med Chem 40:2374-85 (1997) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50059223
Synonyms:
4-[5-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-1-(3-phenyl-propyl)-piperidine | CHEMBL77017
Type:
Small organic molecule
Emp. Form.:
C23H26ClN3
Mol. Mass.:
379.926
SMILES:
Clc1ccc(cc1)-c1cc([nH]n1)C1CCN(CCCc2ccccc2)CC1
Structure:
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