Target
Neutrophil elastase
Ligand
BDBM50031199
Substrate
n/a
Meas. Tech.
ChEMBL_63839 (CHEMBL674889)
Ki
4.7±n/a nM
Citation
 Veale, CABernstein, PRBohnert, CMBrown, FJBryant, CDamewood, JREarley, RFeeney, SWEdwards, PDGomes, BHulsizer, JMKosmider, BJKrell, RDMoore, GSalcedo, TWShaw, ASilberstein, DSSteelman, GBStein, MStrimpler, AThomas, RMVacek, EPWilliams, JCWolanin, DJWoolson, S Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase. J Med Chem 40:3173-81 (1997) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50031199
Synonyms:
((S)-1-{(S)-2-[(S)-1-(Benzooxazole-2-carbonyl)-2-methyl-propylcarbamoyl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid benzyl ester | CHEMBL108783 | Cbz-Val-Pro-Val-(2-benzoxazole)
Type:
Small organic molecule
Emp. Form.:
C30H36N4O6
Mol. Mass.:
548.63
SMILES:
CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)c1nc2ccccc2o1
Structure:
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