Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM50061173
Substrate
n/a
Meas. Tech.
ChEMBL_50387 (CHEMBL662843)
IC50
1500±n/a nM
Citation
 Ling, YZLi, JSLiu, YKato, KKlus, GTBrodie, A 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha). J Med Chem 40:3297-304 (1997) [PubMed]  Article 
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
Enzyme
Mol. Mass.:
57255.68
Organism:
Rattus norvegicus (Rat)
Description:
P11715
Residue:
507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
  
Inhibitor
Name:
BDBM50061173
Synonyms:
(10R,13S)-10,13-Dimethyl-17-(2-phenyl-2H-pyrazol-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol | CHEMBL114864
Type:
Small organic molecule
Emp. Form.:
C28H34N2O
Mol. Mass.:
414.5824
SMILES:
C[C@]12CCC3C(CC=C4CC(O)CC[C@]34C)C1CC=C2c1ccnn1-c1ccccc1 |c:21,t:7|
Structure:
Search PDB for entries with ligand similarity: