Reaction Details Report a problem with these data
Target
Vesicular acetylcholine transporter
Ligand
BDBM50039621
Substrate
n/a
Meas. Tech.
ChEMBL_213558 (CHEMBL817828)
Ki
0.360000±n/a nM
Citation
 Efange, SM; Kamath, AP; Khare, AB; Kung, MP; Mach, RH; Parsons, SM N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters. J Med Chem 40:3905-14 (1998) [PubMed]  Article 
Target
Name:
Vesicular acetylcholine transporter
Synonyms:
SLC18A3 | Solute carrier family 18 member 3 | VACHT | VACHT_HUMAN
Type:
PROTEIN
Mol. Mass.:
56900.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507628
Residue:
532
Sequence:
MESAEPAGQARAAATKLSEAVGAALQEPRRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGGEGPTRTPEVWEPTLPLPTPANASAYTANTSASPTAAWPAGSALRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVLFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMAWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGASSCIVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLRERPVSGQDGEPRSPPGPFDACEDDYNYYYTRS
  
Inhibitor
Name:
BDBM50039621
Synonyms:
3-spiro[2,3-dihydro-1H-indene-1,4'-(hexahydropyridine)]-1-yl-(2R,3R)-1,2,3,4-tetrahydro-2-naphthalenol | CHEMBL87594
Type:
Small organic molecule
Emp. Form.:
C23H27NO
Mol. Mass.:
333.4666
SMILES:
O[C@@H]1Cc2ccccc2C[C@H]1N1CCC2(CCc3ccccc23)CC1
Structure:
Search PDB for entries with ligand similarity: