Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM14775
Substrate
n/a
Meas. Tech.
ChEMBL_155175 (CHEMBL761822)
IC50
3.8±n/a nM
Citation
 Kleinman, EFCampbell, EGiordano, LACohan, VLJenkinson, THCheng, JBShirley, JTPettipher, ERSalter, EDHibbs, TADiCapua, FMBordner, J Striking effect of hydroxamic acid substitution on the phosphodiesterase type 4 (PDE4) and TNF alpha inhibitory activity of two series of rolipram analogues: implications for a new active site model of PDE4. J Med Chem 41:266-70 (1998) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
3',5'-cyclic phosphodiesterase | DPDE1 | NP_000914.2 | PDE21 | PDE4C | PDE4C1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79875.54
Organism:
Homo sapiens (Human)
Description:
Q08493
Residue:
712
Sequence:
MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
  
Inhibitor
Name:
BDBM14775
Synonyms:
3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide | 3-cyclopentyloxy-N-(3,5-dichloropyridin-4-yl)-4-methoxy-benzamide | CHEMBL42126 | Cpodpmb | Piclamilast | RPR-73401
Type:
Small organic molecule
Emp. Form.:
C18H18Cl2N2O3
Mol. Mass.:
381.253
SMILES:
COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl
Structure:
Search PDB for entries with ligand similarity: