Reaction Details Report a problem with these data
Target
Neutrophil collagenase
Ligand
BDBM50062462
Substrate
n/a
Meas. Tech.
ChEMBL_105076 (CHEMBL711321)
Ki
189000±n/a nM
Citation
 Graf von Roedern, E; Grams, F; Brandstetter, H; Moroder, L Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). J Med Chem 41:339-45 (1998) [PubMed]  Article 
Target
Name:
Neutrophil collagenase
Synonyms:
CLG1 | MMP-8 | MMP8 | MMP8_HUMAN | Matrix metalloproteinase-8 | Neutrophil collagenase precursor | PMNL collagenase | PMNL-CL
Type:
Enzyme
Mol. Mass.:
53413.48
Organism:
Homo sapiens (Human)
Description:
P22894
Residue:
467
Sequence:
MFSLKTLPFLLLLHVQISKAFPVSSKEKNTKTVQDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLNVTGKPNEETLDMMKKPRCGVPDSGGFMLTPGNPKWERTNLTYRIRNYTPQLSEAEVERAIKDAFELWSVASPLIFTRISQGEADINIAFYQRDHGDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWTNTSANYNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPIQPTGPSTPKPCDPSLTFDAITTLRGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAVFYRSKTYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAFDLIAQRVTRVARGNKWLNCRYG
  
Inhibitor
Name:
BDBM50062462
Synonyms:
2-Hydroxycarbamoyl-4-phenyl-butyric acid ethyl ester | CHEMBL116523 | ethyl 2-(hydroxycarbamoyl)-4-phenylbutanoate
Type:
Small organic molecule
Emp. Form.:
C13H17NO4
Mol. Mass.:
251.2784
SMILES:
CCOC(=O)C(CCc1ccccc1)C(=O)NO
Structure:
Search PDB for entries with ligand similarity: