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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50062570
Substrate
n/a
Meas. Tech.
ChEMBL_138688 (CHEMBL749925)
IC50
4.4±n/a nM
Citation
 Ward, JS; Merritt, L; Calligaro, DO; Bymaster, FP; Shannon, HE; Mitch, CH; Whitesitt, C; Brunsting, D; Sheardown, MJ; Olesen, PH; Swedberg, MD; Jeppesen, L; Sauerberg, P 1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists. J Med Chem 41:379-92 (1998) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50062570
Synonyms:
3-(4-Propylsulfanyl-[1,2,5]thiadiazol-3-yloxy)-1-aza-bicyclo[2.2.1]heptane | CHEMBL126846
Type:
Small organic molecule
Emp. Form.:
C11H17N3OS2
Mol. Mass.:
271.402
SMILES:
CCCSc1nsnc1OC1CN2CCC1C2 |THB:9:10:16:14.13|
Structure:
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