Reaction Details Report a problem with these data
Target
Cyclic AMP-dependent transcription factor ATF-1
Ligand
BDBM50062668
Substrate
n/a
Meas. Tech.
ChEMBL_27877 (CHEMBL640575)
IC50
4000±n/a nM
Citation
 Sullivan, RW; Bigam, CG; Erdman, PE; Palanki, MS; Anderson, DW; Goldman, ME; Ransone, LJ; Suto, MJ 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-kappa B- and AP-1-mediated gene expression identified using solution-phase combinatorial chemistry. J Med Chem 41:413-9 (1998) [PubMed]  Article 
Target
Name:
Cyclic AMP-dependent transcription factor ATF-1
Synonyms:
ATF1 | ATF1_HUMAN | Activating transcription factor 1 | Cyclic AMP-dependent transcription factor ATF-1 | Protein TREB36 | cAMP-dependent transcription factor ATF-1
Type:
PROTEIN
Mol. Mass.:
29236.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_27877
Residue:
271
Sequence:
MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILARRPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNKSV
  
Inhibitor
Name:
BDBM50062668
Synonyms:
2-Piperidin-1-yl-4-trifluoromethyl-pyrimidine-5-carboxylic acid (3,5-dichloro-phenyl)-amide | CHEMBL335655
Type:
Small organic molecule
Emp. Form.:
C17H15Cl2F3N4O
Mol. Mass.:
419.228
SMILES:
FC(F)(F)c1nc(ncc1C(=O)Nc1cc(Cl)cc(Cl)c1)N1CCCCC1
Structure:
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