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Reaction Details
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TargetEDNRA
LigandBDBM50065518
Substrate/Competitorn/a
Meas. Tech.ChEMBL_63348
IC50 8±n/a nM
Citation Astles, PCBrown, TJHalley, FHandscombe, CMHarris, NVMcCarthy, CMcLay, IMLockey, PMajid, TPorter, BRoach, AGSmith, CWalsh, R Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives. J Med Chem41:2745-53 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
EDNRA
Name:Endothelin receptor
Synonyms:ENDOTHELIN A | Endothelin receptor | Endothelin-1 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:48256.91
Organism:RAT
Description:ENDOTHELIN A EDNRA RAT::P26684
Residue:426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCM
LNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSS
HKDSMN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50065518
NameBDBM50065518
Synonyms:4-[2-Cyano-5-(thiophen-3-ylmethoxy)-phenoxy]-4-o-tolyl-butyric acid | CHEMBL90320
TypeSmall organic molecule
Emp. Form.C23H21NO4S
Mol. Mass.407.482
SMILESCc1ccccc1C(CCC(O)=O)Oc1cc(OCc2ccsc2)ccc1C#N
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a