Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50057436
Substrate
n/a
Meas. Tech.
ChEMBL_1127 (CHEMBL616072)
Ki
0.221±n/a nM
Citation
 Yasunaga, TKimura, TNaito, RKontani, TWanibuchi, FYamashita, HNomura, TTsukamoto, SYamaguchi, TMase, T Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists. J Med Chem 41:2765-78 (1998) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50057436
Synonyms:
CHEMBL25213 | [2-(6-Fluoro-chroman-8-yloxy)-ethyl]-[4-(4-methoxy-phenyl)-butyl]-amine
Type:
Small organic molecule
Emp. Form.:
C22H28FNO3
Mol. Mass.:
373.461
SMILES:
COc1ccc(CCCCNCCOc2cc(F)cc3CCCOc23)cc1
Structure:
Search PDB for entries with ligand similarity: