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Target
Poly [ADP-ribose] polymerase 2
Ligand
BDBM50511566
Substrate
n/a
Meas. Tech.
ChEMBL_1844996 (CHEMBL4345423)
IC50
2717±n/a nM
Citation
 Shirai, F; Mizutani, A; Yashiroda, Y; Tsumura, T; Kano, Y; Muramatsu, Y; Chikada, T; Yuki, H; Niwa, H; Sato, S; Washizuka, K; Koda, Y; Mazaki, Y; Jang, MK; Yoshida, H; Nagamori, A; Okue, M; Watanabe, T; Kitamura, K; Shitara, E; Honma, T; Umehara, T; Shirouzu, M; Fukami, T; Seimiya, H; Yoshida, M; Koyama, H Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer. J Med Chem 63:4183-4204 (2020) [PubMed]  Article 
Target
Name:
Poly [ADP-ribose] polymerase 2
Synonyms:
(ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2)
Type:
Enzyme
Mol. Mass.:
66225.70
Organism:
Homo sapiens (Human)
Description:
Q9UGN5
Residue:
583
Sequence:
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKDRTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
  
Inhibitor
Name:
BDBM50511566
Synonyms:
CHEMBL4448872
Type:
Small organic molecule
Emp. Form.:
C22H26F2N4O2
Mol. Mass.:
416.4642
SMILES:
OCCN1CC2(CCN(CC2)c2nc3CCCCc3c(=O)[nH]2)c2c1cc(F)cc2F
Structure:
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