Reaction Details
Report a problem with these data
Report a problem with these dataTarget
B-cell lymphoma 6 protein
Ligand
BDBM50511627
Substrate
n/a
Meas. Tech.
ChEMBL_1845269 (CHEMBL4345696)
IC50
310±n/a nM
Citation
Bellenie, BR; Cheung, KJ; Varela, A; Pierrat, OA; Collie, GW; Box, GM; Bright, MD; Gowan, S; Hayes, A; Rodrigues, MJ; Shetty, KN; Carter, M; Davis, OA; Henley, AT; Innocenti, P; Johnson, LD; Liu, M; de Klerk, S; Le Bihan, YV; Lloyd, MG; McAndrew, PC; Shehu, E; Talbot, R; Woodward, HL; Burke, R; Kirkin, V; van Montfort, RLM; Raynaud, FI; Rossanese, OW; Hoelder, S Achieving J Med Chem 63:4047-4068 (2020) [PubMed] Article More Info.:
Target
Name:
B-cell lymphoma 6 protein
Synonyms:
B-cell lymphoma 5 protein | B-cell lymphoma 6 protein | BCL-5 | BCL-6 | BCL5 | BCL6 | BCL6_HUMAN | BCoR-BCL6 | LAZ3 | Protein LAZ-3 | ZBTB27 | ZNF51 | Zinc finger and BTB domain-containing protein 27 | Zinc finger protein 51
Type:
PROTEIN
Mol. Mass.:
78866.89
Organism:
Homo sapiens
Description:
ChEMBL_117695
Residue:
706
Sequence:
MASPADSCIQFTRHASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFCILLDFMYTSRLNLREGNIMAVMATAMYLQMEHVVDTCRKFIKASEAEMVSAIKPPREEFLNSRMLMPQDIMAYRGREVVENNLPLRSAPGCESRAFAPSLYSGLSTPPASYSMYSHLPVSSLLFSDEEFRDVRMPVANPFPKERALPCDSARPVPGEYSRPTLEVSPNVCHSNIYSPKETIPEEARSDMHYSVAEGLKPAAPSARNAPYFPCDKASKEEERPSSEDEIALHFEPPNAPLNRKGLVSPQSPQKSDCQPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKFIVLNSLNQNAKPEGPEQAELGRLSPRAYTAPPACQPPMEPENLDLQSPTKLSASGEDSTIPQASRLNNIVNRSMTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSCENGAFFCNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSATDLPPELPKAC
Inhibitor
Name:
BDBM50511627
Synonyms:
CHEMBL4587209
Type:
Small organic molecule
Emp. Form.:
C22H27ClF2N6O2
Mol. Mass.:
480.939
SMILES:
Cn1c2ccc(Nc3nc(ncc3Cl)N3CCC(F)(F)CC3)cc2n(CCC(C)(C)O)c1=O
Structure:
