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TargetTrypsin
LigandBDBM50066637
Substrate/Competitorn/a
Meas. Tech.ChEMBL_212528
Ki 220±n/a nM
Citation Phillips, GBBuckman, BODavey, DDEagen, KAGuilford, WJHinchman, JHo, EKoovakkat, SLiang, ALight, DRMohan, RNg, HPPost, JMShaw, KJSmith, DSubramanyam, BSullivan, METrinh, LVergona, RWalters, JWhite, KWhitlow, MWu, SXu, WMorrissey, MM Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa. J Med Chem41:3557-62 (1998) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Trypsin
Name:Trypsin I
Synonyms:Beta-Trypsin | Cationic trypsin | Trypsin I
Type:Enzyme
Mol. Mass.:25790.52
Organism:Bos taurus (bovine)
Description:P00760
Residue:246
Sequence:
MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50066637
NameBDBM50066637
Synonyms:2-(5-Carbamimidoyl-2-hydroxy-phenoxy)-6-[3-(1-methyl-4,5-dihydro-1H-imidazol-2-yl)-phenoxy]-isonicotinic acid | CHEMBL84065
TypeSmall organic molecule
Emp. Form.C23H21N5O5
Mol. Mass.447.4433
SMILESCN1CCN=C1c1cccc(Oc2cc(cc(Oc3cc(ccc3O)C(N)=N)n2)C(O)=O)c1 |c:4|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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