Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetChymase
LigandBDBM50068901
Substrate/Competitorn/a
Meas. Tech.ChEBML_49442
Ki 1.3±n/a nM
Citation Eda, MAshimori, AAkahoshi, FYoshimura, TInoue, YFukaya, CNakajima, MFukuyama, HImada, TTakai, SShiota, NMiyazaki, MNakamura, N Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites. Bioorg Med Chem Lett8:913-8 (1999) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chymase
Name:Chymase
Synonyms:Alpha-chymase | Chymase precursor | Mast cell protease I
Type:Enzyme
Mol. Mass.:27340.12
Organism:Homo sapiens (Human)
Description:n/a
Residue:247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNF
VLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKA
SLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRD
FDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWI
NQILQAN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50068901
NameBDBM50068901
Synonyms:3-[2,2-Difluoro-4-({(S)-1-[(S)-3-methyl-2-(3-phenyl-propionylamino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-oxo-5-phenyl-pentanoylamino]-benzoic acid | CHEMBL353816
TypeSmall organic molecule
Emp. Form.C37H40F2N4O7
Mol. Mass.690.7329
SMILESCC(C)[C@H](NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NC(Cc1ccccc1)C(=O)C(F)(F)C(=O)Nc1cccc(c1)C(O)=O
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a