Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50068918
Substrate
n/a
Meas. Tech.
ChEBML_49443
Ki
3±n/a nM
Citation
Eda, M; Ashimori, A; Akahoshi, F; Yoshimura, T; Inoue, Y; Fukaya, C; Nakajima, M; Fukuyama, H; Imada, T; Takai, S; Shiota, N; Miyazaki, M; Nakamura, N Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site. Bioorg Med Chem Lett 8:919-24 (1999) [PubMed] Article
More Info.:
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
Inhibitor
Name:
BDBM50068918
Synonyms:
(S)-4-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-5-[(S)-2-((S)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-5-oxo-pentanoic acid | CHEMBL355430
Type:
Small organic molecule
Emp. Form.:
C34H44N4O9
Mol. Mass.:
652.7346
SMILES:
CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)OC