Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor A
Ligand
BDBM50514581
Substrate
n/a
Meas. Tech.
ChEMBL_1857650 (CHEMBL4358379)
Ki
1700±n/a nM
Citation
 Juillerat-Jeanneret, L The Other Angiotensin II Receptor: AT J Med Chem 63:1978-1995 (2020) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor A
Synonyms:
AGTRA_RAT | ANGIOTENSIN AT1 | Agtr1 | Agtr1a | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | At1a | Type-1A angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40910.53
Organism:
RAT
Description:
ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:
359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
  
Inhibitor
Name:
BDBM50514581
Synonyms:
CHEMBL1885579
Type:
Small organic molecule
Emp. Form.:
C52H69N13O11
Mol. Mass.:
1052.1848
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCNC(=O)[C@H](CCCN=C(N)N)NC(=O)OCc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c1cccnc1)C(O)=O |wD:15.23,4.4,25.54,55.67,33.42,8.7,2.2,(24.22,-16.21,;22.68,-16.15,;21.86,-17.46,;22.57,-18.82,;20.32,-17.4,;19.5,-18.7,;17.96,-18.64,;17.24,-17.28,;17.14,-19.94,;17.71,-21.37,;16.52,-22.36,;15.22,-21.54,;15.6,-20.04,;14.61,-18.86,;15.15,-17.42,;13.1,-19.12,;12.14,-20.33,;12.72,-21.76,;14.21,-22.14,;14.31,-23.68,;12.88,-24.25,;11.89,-23.07,;12.52,-17.69,;11,-17.47,;10.05,-18.68,;10.43,-16.04,;8.9,-15.82,;8.33,-14.39,;6.81,-14.17,;6.24,-12.74,;4.71,-12.52,;4.14,-11.09,;5.09,-9.88,;2.62,-10.87,;1.66,-12.08,;.14,-11.86,;-.81,-13.07,;-2.34,-12.85,;-3.29,-14.06,;-2.72,-15.49,;-4.81,-13.84,;2.05,-9.44,;.52,-9.22,;-.43,-10.43,;-.05,-7.79,;-1.57,-7.57,;-2.15,-6.14,;-3.67,-5.92,;-4.24,-4.49,;-3.29,-3.28,;-1.76,-3.5,;-1.19,-4.93,;11.38,-14.83,;12.91,-15.05,;13.48,-16.48,;13.86,-13.84,;13.29,-12.41,;11.76,-12.19,;10.81,-13.4,;9.29,-13.18,;8.71,-11.75,;7.19,-11.53,;9.67,-10.54,;11.19,-10.76,;15.38,-14.06,;16.34,-12.85,;15.76,-11.42,;17.86,-13.07,;18.81,-11.86,;20.34,-12.08,;20.91,-13.51,;19.96,-14.72,;18.43,-14.5,;19.6,-16.03,;20.62,-14.82,;18.06,-15.97,)|
Structure:
Search PDB for entries with ligand similarity: