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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50069883
Substrate
n/a
Meas. Tech.
ChEBML_28186
IC50
7±n/a nM
Citation
 Lee, HT; Roark, WH; Picard, JA; Sliskovic, DR; Roth, BD; Stanfield, RL; Hamelehle, KL; Bousley, RF; Krause, BR Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates. Bioorg Med Chem Lett 8:289-94 (1999) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50069883
Synonyms:
(2,6-Diisopropyl-phenylcarbamoyl)-methanesulfonic acid 2,6-diisopropyl-phenyl ester | CHEMBL101096
Type:
Small organic molecule
Emp. Form.:
C26H37NO4S
Mol. Mass.:
459.641
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)CS(=O)(=O)Oc1c(cccc1C(C)C)C(C)C
Structure:
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