Target
17-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50515433
Substrate
n/a
Meas. Tech.
ChEMBL_1861097 (CHEMBL4361953)
IC50
1.000000±n/a nM
Citation
 Abdelsamie, ASSalah, MSiebenbürger, LMerabet, AScheuer, CFrotscher, MMüller, STZierau, OVollmer, GMenger, MDLaschke, MWvan Koppen, CJMarchais-Oberwinkler, SHartmann, RW Design, Synthesis, and Biological Characterization of Orally Active 17?-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis. J Med Chem 62:7289-7301 (2019) [PubMed]  Article 
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase
Type:
Oxidoreductase; single-pass type II membrane protein
Mol. Mass.:
42795.29
Organism:
Homo sapiens (Human)
Description:
Enzyme was partially purified from human placenta.
Residue:
387
Sequence:
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
  
Inhibitor
Name:
BDBM50515433
Synonyms:
CHEMBL4585585
Type:
Small organic molecule
Emp. Form.:
C24H15F4NO4S2
Mol. Mass.:
521.504
SMILES:
Cc1ccc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc(s1)C(=O)c1cc(F)c(F)c(O)c1F
Structure:
Search PDB for entries with ligand similarity: