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Target
Serine protease 1
Ligand
BDBM50070823
Substrate
n/a
Meas. Tech.
ChEBML_210683
Ki
1400±n/a nM
Citation
 Isaacs, RC; Cutrona, KJ; Newton, CL; Sanderson, PE; Solinsky, MG; Baskin, EP; Chen, IW; Cooper, CM; Cook, JJ; Gardell, SJ; Lewis, SD; Lucas, RJ; Lyle, EA; Lynch, JJ; Naylor-Olsen, AM; Stranieri, MT; Vastag, K; Vacca, JP C6 modification of the pyridinone core of thrombin inhibitor L-374,087 as a means of enhancing its oral absorption. Bioorg Med Chem Lett 8:1719-24 (1999) [PubMed]  Article 
Target
Name:
Serine protease 1
Synonyms:
Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1
Type:
Enzyme
Mol. Mass.:
26557.80
Organism:
Homo sapiens (Human)
Description:
P07477
Residue:
247
Sequence:
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS
  
Inhibitor
Name:
BDBM50070823
Synonyms:
CHEMBL45480 | N-(6-Amino-2-methyl-pyridin-3-ylmethyl)-2-(2-oxo-3-phenylmethanesulfonylamino-6-propyl-2H-pyridin-1-yl)-acetamide
Type:
Small organic molecule
Emp. Form.:
C24H29N5O4S
Mol. Mass.:
483.583
SMILES:
CCCc1ccc(NS(=O)(=O)Cc2ccccc2)c(=O)n1CC(=O)NCc1ccc(N)nc1C
Structure:
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