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Target
Farnesyl pyrophosphate synthase
Ligand
BDBM50247920
Substrate
n/a
Meas. Tech.
ChEMBL_1866162 (CHEMBL4367137)
IC50
15000±n/a nM
Citation
 Pativada, T; Kim, MH; Lee, JH; Hong, SS; Choi, CW; Choi, YH; Kim, WJ; Song, DW; Park, SI; Lee, EJ; Seo, BY; Kim, H; Kim, HK; Lee, KH; Ahn, SK; Ku, JM; Park, GH Benzylideneacetone Derivatives Inhibit Osteoclastogenesis and Activate Osteoblastogenesis Independently Based on Specific Structure-Activity Relationship. J Med Chem 62:6063-6082 (2019) [PubMed]  Article 
Target
Name:
Farnesyl pyrophosphate synthase
Synonyms:
(2E,6E)-farnesyl diphosphate synthase | 2.5.1.1 | 2.5.1.10 | CR 39 | Cholesterol-regulated 39 kDa protein | Dimethylallyltranstransferase | FPP synthase | FPPS_MOUSE | FPS | Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase | Fdps | Geranyltranstransferase
Type:
PROTEIN
Mol. Mass.:
40577.01
Organism:
Mus musculus
Description:
ChEMBL_119164
Residue:
353
Sequence:
MNGNQKLDAYNQEKQNFIQHFSQIVKVLTEKELGHPEIGDAIARLKEVLEYNALGGKYNRGLTVVQAFQELVEPKKQDAESLQRALTVGWCVELLQAFFLVSDDIMDSSLTRRGQICWYQKPGIGLDAINDALLLEASIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLMTAPQGHVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILMEMGEFFQVQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRASPQQRQILEENYGQKDPEKVARVKALYEALDLQSAFFKYEEDSYNRLKSLIEQCSAPLPPSIFMELANKIYKRRK
  
Inhibitor
Name:
BDBM50247920
Synonyms:
Alendronate Sodium | Binosto | Fosamax | G-704650 | MK-217
Type:
Small organic molecule
Emp. Form.:
C4H12NNaO7P2
Mol. Mass.:
271.0779
SMILES:
[Na+].NCCCC(O)(P(O)(O)=O)P(O)([O-])=O
Structure:
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