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Target
Cathepsin D
Ligand
BDBM50072542
Substrate
n/a
Meas. Tech.
ChEBML_45174
Ki
1800±n/a nM
Citation
 Carroll, CD; Johnson, TO; Tao, S; Lauri, G; Orlowski, M; Gluzman, IY; Goldberg, DE; Dolle, RE Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D. Bioorg Med Chem Lett 8:3203-6 (1999) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50072542
Synonyms:
4-(2-Phenethyloxy-ethyl)-1-[3-(3,4,5-trimethoxy-phenyl)-propionyl]-piperazine-2-carboxylic acid ((1S,2S)-1-benzyl-3-butylcarbamoyl-2-hydroxy-propyl)-amide | CHEMBL431861
Type:
Small organic molecule
Emp. Form.:
C42H58N4O8
Mol. Mass.:
746.9319
SMILES:
CCCCNC(=O)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)C1CN(CCOCCc2ccccc2)CCN1C(=O)CCc1cc(OC)c(OC)c(OC)c1
Structure:
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