Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50072746
Substrate
n/a
Meas. Tech.
ChEBML_202316
Ki
33±n/a nM
Citation
 Perez, M; Pauwels, PJ; Pallard-Sigogneau, I; Fourrier, C; Chopin, P; Palmier, C; Colovray, V; Halazy, S Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors. Bioorg Med Chem Lett 8:3423-8 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50072746
Synonyms:
(S)-1-(Naphthalen-1-yloxy)-3-[(S)-3-phenyl-3-(4-trifluoromethyl-phenoxy)-propylamino]-propan-2-ol | CHEMBL116626
Type:
Small organic molecule
Emp. Form.:
C29H28F3NO3
Mol. Mass.:
495.5327
SMILES:
O[C@@H](CNCC[C@H](Oc1ccc(cc1)C(F)(F)F)c1ccccc1)COc1cccc2ccccc12
Structure:
Search PDB for entries with ligand similarity: