Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50074231
Substrate
n/a
Meas. Tech.
ChEMBL_30012 (CHEMBL641303)
Ki
6130±n/a nM
Citation
 Li, AH; Moro, S; Forsyth, N; Melman, N; Ji, XD; Jacobson, KA Synthesis, CoMFA analysis, and receptor docking of 3,5-diacyl-2, 4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J Med Chem 42:706-21 (1999) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_RAT | ADENOSINE A2a | Adenosine A2 receptor | Adenosine A2a receptor (A2a) | Adenosine Receptors A2a (A2a) | Adenosine receptor A2a and A3 | Adenosine receptors A2a | Adora2a | Rat striatal adenosine A2a receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
45015.65
Organism:
Rattus norvegicus (rat)
Description:
Rat A2A receptors expressed in CHO cells.
Residue:
410
Sequence:
MGSSVYITVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGVRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDGNSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCRHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFQAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSATHSGRRPNGYTLGLGGGGSAQGSPRDVELPTQERQEGQEHPGLRGHLVQARVGASSWSSEFAPS
  
Inhibitor
Name:
BDBM50074231
Synonyms:
4,6-Diethyl-5-ethylsulfanylcarbonyl-2-phenyl-nicotinic acid ethyl ester | CHEMBL321845 | ethyl 4,6-diethyl-5-(ethylthiocarbonyl)-2-phenylnicotinate
Type:
Small organic molecule
Emp. Form.:
C21H25NO3S
Mol. Mass.:
371.493
SMILES:
CCOC(=O)c1c(CC)c(C(=O)SCC)c(CC)nc1-c1ccccc1
Structure:
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