Target
Endothelial lipase
Ligand
BDBM151238
Substrate
n/a
Meas. Tech.
ChEMBL_1888464 (CHEMBL4390141)
IC50
190±n/a nM
Citation
 Kim, SHJohnson, JAJiang, JParkhurst, BPhillips, MPi, ZQiao, JXTora, GYe Chen, ALiu, EYin, XYang, RZhao, LTaylor, DSBasso, MBehnia, KOnorato, JChen, XQAbell, LMLu, HLocke, GCaporuscio, CAdam, LPGordon, DWexler, RRFinlay, HJ Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase. Bioorg Med Chem Lett 29:1918-1921 (2019) [PubMed]  Article 
Target
Name:
Endothelial lipase
Synonyms:
EDL | Endothelial cell-derived lipase | Endothelial lipase | Endothelial lipase (EL) | LIPE_MOUSE | Lipg
Type:
Protein
Mol. Mass.:
56643.58
Organism:
Mus musculus (Mouse)
Description:
Q9WVG5
Residue:
500
Sequence:
MRNTVFLLGFWSVYCYFPAGSITTLRPQGSLRDEHHKPTGVPATARPSVAFNIRTSKDPEQEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFESWLHKLVSALQMREKDANVVVVDWLPLAHQLYTDAVNNTRVVGQRVAGMLDWLQEKEEFSLGNVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFVDVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVIGSFAYGTISEMVKCEHERAVHLFVDSLVNQDKPSFAFQCTDSSRFKRGICLSCRKNRCNNIGYNAKKMRKKRNSKMYLKTRAGMPFKVYHYQLKVHMFSYNNSGDTQPTLYITLYGSNADSQNLPLEIVEKIELNATNTFLVYTEEDLGDLLKMRLTWEGVAHSWYNLWNEFRNYLSQPSNPSRELYIRRIRVKSGETQRKVTFCTQDPTKSSISPGQELWFHKCQDGWKMKNKTSPFVNLA
  
Inhibitor
Name:
BDBM151238
Synonyms:
US8987314, B34
Type:
Small organic molecule
Emp. Form.:
C21H28N6O6S3
Mol. Mass.:
556.679
SMILES:
CS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1cnn(CCN2CCOCC2)c1
Structure:
Search PDB for entries with ligand similarity: