Reaction Details Report a problem with these data
Target
Beta-lactamase TEM
Ligand
BDBM50526862
Substrate
n/a
Meas. Tech.
ChEMBL_1901389 (CHEMBL4403611)
Ki
110±n/a nM
Citation
 González-Bello, C; Rodríguez, D; Pernas, M; Rodríguez, Á; Colchón, E ?-Lactamase Inhibitors To Restore the Efficacy of Antibiotics against Superbugs. J Med Chem 63:1859-1881 (2020) [PubMed]  Article 
Target
Name:
Beta-lactamase TEM
Synonyms:
BLAT_ECOLX | Bacterial beta-lactamase TEM | Beta-lactamase (TEM-1) | Beta-lactamase TEM | Beta-lactamase TEM-1 | Beta-lactamase TEM-1b | Beta-lactamase TEM1D | Beta-lactamase TEM1E | Beta-lactamase TEM1F | TEM beta lactamase | TEM extended-spectrum beta-lactamase | TEM-1 beta-lactamase | bla
Type:
Enzyme
Mol. Mass.:
31512.33
Organism:
Escherichia coli
Description:
P62593
Residue:
286
Sequence:
MSIQHFRVALIPFFAAFCLPVFAHPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRVDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPAAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW
  
Inhibitor
Name:
BDBM50526862
Synonyms:
CHEMBL1231367
Type:
Small organic molecule
Emp. Form.:
C11H14BNO5
Mol. Mass.:
251.044
SMILES:
CC(=O)N[C@@H](Cc1cccc(c1)C(O)=O)B(O)O |r|
Structure:
Search PDB for entries with ligand similarity: