Target
Polyunsaturated fatty acid lipoxygenase ALOX15B
Ligand
BDBM50528942
Substrate
n/a
Meas. Tech.
ChEMBL_1906828 (CHEMBL4409186)
IC50
3800±n/a nM
Citation
 Czyzyk, DJValhondo, MDeiana, LTirado-Rives, JJorgensen, WLAnderson, KS Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article 
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX15B
Synonyms:
Alox15b | Arachidonate 15-lipoxygenase, type II | LX15B_RAT
Type:
PROTEIN
Mol. Mass.:
76140.88
Organism:
Rattus norvegicus
Description:
ChEMBL_12426
Residue:
677
Sequence:
MAKFRVRVSTGEACGAGTWDKVSVSIVGTHGESPLVPLDHLGKEFSAGAEEDFEVTLPQDVGTVLMLRIHKAPPEAPLPLLSFPPDAWYCRWFELEWLPGAALRFPCYQWLEGAGELVLREGAAKVSWQDHHRTLQDQRQKELESRKDMYSWKTYIEGWPHCLDHETVKDLDLNIKYSAMKNAKFFFKAQSAFTELKFKGLLDRTGLWRSLREMKRMFNFHNTPAAEYVFAHWQEDAFFASQFLNGLNPVLIRRCRRLPENFPVTDEMVAPVLGPGTSLQAELEKGSLFLVDHGILSGVQTNVINGKPQFSAAPMTLLYQSPGSGPLLPIAIQLKQTPGPDNPIFLPSDDKWDWLLAKTWVRNAEFSIHEALTHLLHAHLIPEVFALATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIAPGKVVDKSTGLGIGGFSDLIKRNMEQLSYSVLCLPEDIRARDVGDLPGYYYRDDGMQIWSAIRSFVSEIVDIYYPSDASVRDDQELQAWVGEIFSEGFLSQESSGMPSLLDTQEALVQYVTMVIFTCSAKHAAVSASQFDSCVWMPNLPPSMQLPPPTSKGQASPEGFIATLPAVNATCDVIIALWLLSKEPGDRRPLGHYPDEHFTEEVPRRSIAAFQRKLIQISSGIRKRNQSLALPYTYLDPPLIENSVSI
  
Inhibitor
Name:
BDBM50528942
Synonyms:
CHEMBL4442032
Type:
Small organic molecule
Emp. Form.:
C21H23N5O4
Mol. Mass.:
409.4384
SMILES:
Nc1nc2[nH]cc(Cc3ccc(cc3)C(=O)NC3CCCCC3C(O)=O)c2c(=O)[nH]1
Structure:
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