Reaction Details Report a problem with these data
Target
Cytosolic phospholipase A2
Ligand
BDBM50085494
Substrate
n/a
Meas. Tech.
ChEBML_156221
IC50
11700±n/a nM
Citation
 Lucas, R; Ubeda, A; Payá, M; Alves, M; del Olmo, E; López, JL; San Feliciano, A Synthesis and enzyme inhibitory activities of a series of lipidic diamine and aminoalcohol derivatives on cytosolic and secretory phospholipases A2. Bioorg Med Chem Lett 10:285-8 (2000) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2
Synonyms:
Cpla2 | PA24A_MOUSE | Pla2g4 | Pla2g4a
Type:
PROTEIN
Mol. Mass.:
85206.20
Organism:
Mus musculus
Description:
ChEMBL_156221
Residue:
748
Sequence:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSMTLSSLKEKVNAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLRDFSSQDSFDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPTV
  
Inhibitor
Name:
BDBM50085494
Synonyms:
1,1,1-Trifluoro-heptadecan-2-oneor(Palmitoyl trifluoromethyl ketone (PTK)) | 1,1,1-trifluoroheptadecan-2-one | CHEMBL99344
Type:
Small organic molecule
Emp. Form.:
C17H31F3O
Mol. Mass.:
308.4226
SMILES:
CCCCCCCCCCCCCCCC(=O)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: